UK Study: HIV Drug Shows Promise Against Dementia

Fierce Biotech reports:

An HIV drug from GSK or ones like it could have new therapeutic potential against neurodegenerative disease, findings in mice suggest.

In a report published April 26 in Neuron, scientists from the University of Cambridge described how they established a link between microglia and autophagy in the etiology of dementia and Huntington’s disease.

They also showed that the HIV drug maraviroc, sold in the U.S. by GSK as Selzentry, reduced levels of key misfolded proteins in mouse models of those conditions. It also improved cognition in mice with dementia.

Read the full article.

There’s much more wonky science talk at the link.

Maraviroc has shown promise in clearing toxic proteins linked to Huntington’s disease and dementia in mice, raising the possibility of repurposing it for neurodegenerative disorders.https://t.co/XfDGFWcko7

— Interesting Engineering (@IntEngineering) April 28, 2023