Via press release from the FDA:
We have been following the discussions and news reports about reducing the number of doses, extending the length of time between doses, changing the dose (half-dose), or mixing and matching vaccines in order to immunize more people against COVID-19.
These are all reasonable questions to consider and evaluate in clinical trials. However, at this time, suggesting changes to the FDA-authorized dosing or schedules of these vaccines is premature and not rooted solidly in the available evidence.
Without appropriate data supporting such changes in vaccine administration, we run a significant risk of placing public health at risk, undermining the historic vaccination efforts to protect the population from COVID-19.
The available data continue to support the use of two specified doses of each authorized vaccine at specified intervals.
For the Pfizer-BioNTech COVID-19 vaccine, the interval is 21 days between the first and second dose. And for the Moderna COVID-19 vaccine, the interval is 28 days between the first and second dose.
A piece in the @nytimes today asserted that the UK “quietly updated its vaccination playbook to allow for a mix and match regimen”.
This is both strictly true and entirely misleading. #mixandmatch #vaccine
Thread… https://t.co/JJEPf6By71— Chris van Tulleken ?️? (@DoctorChrisVT) January 2, 2021
It is NOT now UK policy to give whatever vaccine is at hand for the second shot. But it is an option for a tiny number of individuals where it is not known which vaccine was given first.
— Chris van Tulleken ?️? (@DoctorChrisVT) January 2, 2021
Lets say someone shows up for their second dose and they have lost their card (I have lost mine – luckily I photographed it!) or changed GPs.
— Chris van Tulleken ?️? (@DoctorChrisVT) January 2, 2021
If they are at high risk and they may have difficulty attending again then it “it is reasonable to offer one dose of the locally available product to complete the schedule”.
This is a quote from the “Green Book”.
— Chris van Tulleken ?️? (@DoctorChrisVT) January 2, 2021